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CRDB_PT0030

Publication No.EP1549301
CRDB IDCRDB_PT0030
TitleA method for using tethered bis(polyhydroxyphenyls) and o-alkyl derivatives thereof in treating inflammatory conditions of the central nervous system
CountryEurope
Publication Date06.07.2005
International Classification A61K 31/047
Application No.3736838
Applicant OKLAHOMA MED RES FOUND
InventorHENSLEY KENNETH L
Google Patent Link EP1549301
AbstractThe present invention involves the use tethered bis(polyhydroxyphenyl) compounds to slow the progression of neurological diseases in which pro-inflammatory cytokine stimulation of microglial cells is reasonably anticipated to make a significant contribution to disease pathology. Diseases for which this is the case include amyotrophic lateral sclerosis (AlS) and other motor neuron diseases (MNDs) of similar clinical presentation; Parkinson’s disease (PD); Alzheimer’s disease (AD); spino-bulbar atrophy; (SBA); Huntington’s disease (HD); myasthenia gravis (MG); multiple sclerosis (MS); HIV-associated dementia; fronto-temporal dementia (FTD); stroke; encephalomyelitis; traumatic brain injury; age-related retinal degeneration; and other neurological diseases possessing microglial activation as a contributing pathological feature. Specific examples are presented where the tethered bis(polyhydroxyphenyl) compound is resveratrol; piceatannol; nordihydroguaiaretic acid (NDGA), curcumin, or sesamin.